Hi, we did a research on this and found that many users are having the same problem. Several users started having this issue after Safari 5.0.5. We have also tested this with different libraries (which includes changing adobe acrobat/reader options to display pdf in browser) and none of them worked. It's like it's just impossible to view PDF file in lightbox for Safari. So we are guessing that it's a Safari bug.
However, we have a new workaround for this. Please do the following:
1. Deactivate and delete the currently installed version of the plugin(s).
2. Download a fresh build of the plugin(s) from here:
http://support.tipsandtricks-hq.com/update-request
3. Upload and activate this version of the plugin(s).
Now use any of the following shortcodes to display PDF file in overlay:
For Anchor Text
[wp_lightbox_prettyPhoto_anchor_text_pdf link="http://www.example.com/ebook/sample-ebook.pdf" width="640" height="480" title="Title goes here" text="Click here to open the pdf file"]
For Anchor Image
[wp_lightbox_prettyPhoto_pdf link="http://www.example.com/ebook/sample-ebook.pdf" width="640" height="480" title="Title goes here" source="http://www.example.com/image/anchor-image.png"]
Let me know how it goes.